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KMID : 0043320070300060674
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Archives of Pharmacal Research
2007 Volume.30 No. 6 p.674 ~ p.677
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Cytoprotective Constituent of Hoveniae Lignum on Both Hep G2 Cells and Rat Primary Hepatocytes
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An Ren-Bo
Park Eun-Jeon
Jeong Gil-Saeng
Sohn Dong-Hwan
Kim Youn-Chul
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Abstract
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A phytochemical investigation of the EtOH extract of Hoveniae Lignum yielded four phenolic compounds, phloretin (1), 5-(4’-hydroxyphenyl)-γ-valerolactone (2), (?)-epiafzelechin (3), and maesopsin (4). Compound 1 was hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with an EC50 value of 37.55 ± 0.42 μM. Compound 1 (0.4-200 μM) also significantly reduced tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes as measured by the cellular leakage of lactate dehydrogenase and the level of aspartate transaminase.
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KEYWORD
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Hoveniae Lignum, Phloretin, Chalcone, Cytoprotective, Hep G2, Rat primary hepatocytes
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